Do temperature conditions need to be considered when storing pharmaceutical hard gelatin empty capsules?

Yes, temperature conditions are crucial to consider when storing pharmaceutical hard gelatin empty capsules. Here's why:
Gelatin Integrity: Gelatin, the primary material used in hard gelatin capsules, is sensitive to temperature fluctuations. Extreme temperatures can cause gelatin capsules to become brittle or soft, affecting their integrity and performance during filling and handling processes.
Preventing Deformation: High temperatures can cause gelatin capsules to soften or even melt, leading to deformation and potential leakage of contents. Conversely, low temperatures can make capsules brittle and prone to cracking or breaking.
Maintaining Shelf Life: Storing capsules within the recommended temperature range helps preserve their quality and extend their shelf life. Temperature-controlled storage conditions slow down the degradation of gelatin capsules, ensuring they remain suitable for use over an extended period.
Preventing Moisture Absorption: Temperature fluctuations can also affect humidity levels, leading to moisture absorption by the capsules. Excessive moisture can compromise the capsules' physical properties and promote microbial growth, reducing their quality and safety.

To ensure the quality and integrity of pharmaceutical hard gelatin empty capsules, it's essential to store them in a controlled environment with stable temperature conditions. The recommended temperature range for storage is typically between 15°C to 25°C (59°F to 77°F). Avoid exposing the capsules to extreme heat, cold, or rapid temperature changes, and store them away from direct sunlight and sources of heat or moisture.
By maintaining proper temperature conditions during storage, you can preserve the quality and integrity of pharmaceutical hard gelatin empty capsules, ensuring they meet the required standards for use in pharmaceutical or nutraceutical products.