If the product to be packed in HPMC empty capsules has hygroscopic ingredients, will it affect the stability of the HPMC empty capsules?

HPMC empty capsules have a wide range of applications in the field of drug and health product packaging due to their unique chemical and physical properties. When products that need to be packaged in HPMC empty capsules contain moisture absorbing components, it may indeed have a certain impact on the stability of HPMC empty capsules, but the degree and manner of the impact depend on multiple factors.
Firstly, HPMC, as a cellulose derivative, has a relatively low water content, usually only 5% -7%, and some even less than 3%. This low water content characteristic makes HPMC empty capsules relatively more stable when facing hygroscopic contents. However, if the contents have strong hygroscopicity and are in contact with HPMC capsules for a long time, it may cause an increase in humidity inside the capsules, thereby affecting the toughness and integrity of the capsule shell.
Secondly, the chemical inertness of HPMC makes it compatible with most substances, which reduces the risk of chemical reactions cause to a decrease in capsule stability. However, if there is a special interaction between the moisture absorbing components in the contents and the HPMC capsule shell (although this situation is rare), it may also have adverse effects on the stability of the capsule.