Shaoxing Zhongya Capsule Co., Ltd.

What are the characteristics of HPMC hollow capsules in drug delivery?

Update:14 Feb 2025

1. Environmental protection and safety
HPMC hollow capsules are made of plant cellulose derivatives and are non-animal derived materials that meet the needs of vegetarians and animal welfare. Its chemical inertness, biocompatibility and degradability make it a safe choice for drug carriers.

2. Superior physical and chemical properties
HPMC hollow capsules have good mechanical strength and chemical stability, are not prone to cross-linking reactions, and show good short-term stability at high temperatures. In addition, they can still maintain flexibility under low humidity conditions, avoiding the problem of gelatin capsules becoming brittle and absorbing water under low humidity.

3. Flexible drug release characteristics
HPMC hollow capsules can achieve sustained release, controlled release and even targeted release functions by adjusting wall thickness, composition and coating technology. For example, by optimizing the thickness and composition of the capsule wall, the solubility and release rate of the drug can be regulated under different pH environments, thereby improving the bioavailability of the drug.

4. Wide range of applications
HPMC hollow capsules are suitable for a variety of drug delivery systems, including solid, liquid and semi-solid drugs. It is widely used in all-natural products, moisture-sensitive or hygroscopic contents, dry powder inhalers and enteric coatings.

5. Intestinal protection and targeted release
HPMC capsules are particularly suitable for intestinal protection and targeted release. For example, it shows excellent performance in the release of acidic and heat-sensitive active ingredients, and can quickly release drugs in the gastric acid environment while remaining stable in the intestine, thereby achieving optimal absorption in the upper digestive tract.

6. Advantages of coating technology
The coating technology of HPMC capsules further enhances its application flexibility. For example, enteric coating technology can protect drugs from gastric acid erosion while ensuring their release in the intestine, thereby improving the efficacy and safety of drugs.

7. Strong environmental adaptability
HPMC hollow capsules can still maintain good morphology and performance in a high humidity environment, which makes them highly adaptable under different climatic conditions.

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