Most capsules are made of gelatin. Gelatin itself is a water-soluble protein derived from collagen, the main natural protein component of connective tissue. Gelatin is obtained from the skin and bones of animals through a controlled extraction process. There are many types of gelatin. Capsules are made from pharmaceutical-grade gelatin that meets the stringent requirements of the US Pharmacopeia and other international organizations that set standards for products intended for use in pharmaceuticals.