Why HPMC empty capsules are outstanding in bioavailability?

1. Stable chemical properties
As a cellulose derivative, HPMC is chemically inert and has excellent compatibility with most substances. This means that HPMC hollow capsules are not prone to chemical reactions with drugs or other contents during storage and use, thus ensuring the stability and bioavailability of the drug. In contrast, gelatin hollow capsules may undergo cross-linking reactions with certain contents with special properties (such as contents containing aldehyde groups or reacting to form aldehyde groups under certain conditions), or Maillard reactions with contents with strong reducing properties, all of which may affect the stability and bioavailability of the drug.

2. Good physical properties
HPMC hollow capsules have lower water content and stronger toughness. Its water content is usually about 60% lower than that of gelatin hollow capsules, which makes HPMC hollow capsules more suitable for filling hygroscopic or moisture-sensitive contents to extend the shelf life of the product. At the same time, HPMC hollow capsules also have better toughness and can maintain good performance even when the ambient humidity is low. These physical properties enable HPMC hollow capsules to maintain good morphology and performance during preparation, storage and use, which is conducive to the release and bioavailability of drugs.

3. Unique dissolution properties
HPMC hollow capsules can be stably present in the dissolution medium and have good dissolution properties. Its dissolution rate is moderate, neither too fast to cause sudden release of drugs nor too slow to affect the release efficiency of drugs. This moderate dissolution property enables HPMC hollow capsules to better control the release rate and amount of drugs, thereby improving the bioavailability of drugs. In addition, HPMC hollow capsules also show unique advantages in enteric coating, which can better maintain the permeability in the stomach and have good release in the intestine, which also helps to improve the bioavailability of drugs.

4. Wide range of application fields
HPMC hollow capsules have a wide range of applications, including all-natural products, moisture-sensitive or hygroscopic contents, dry powder inhalers, and enteric coatings. This wide range of applications enables HPMC hollow capsules to adapt to the encapsulation needs of different types of drugs, thereby providing more possibilities for improving the bioavailability of drugs.